Circulating DNA-markers in lung cancer: changes in retrotrasposons methylation status in response therapy and during the post-treatment follow-up /A. A. Ponomaryova, A. Y. Dobrodeev, A. A. Bondar [et.al.]

Электронный ресурс
Другой Автор
Ponomaryova, Anastasia A.
Bondar, A. A.
Cherdyntseva, Nadezhda V.
Zavyalov, A. A.
Tuzikov, S. A.
Vlassov, V. V.
Laktionov, P. P.
Rykova, E. Y.
Dobrodeev, A. Y.
Источник
The 22nd International Charles Heidelberger symposium on cancer research : proceedings of the International symposium, 17-19 September 2018 Tomsk, 2018 P. 88-89
Аннотация
Malignant cell transformation is accompanied by two processes of DNA methylation changes: hypermethylation in CpG islands of tumor suppressor genes and global hypomethylation in repetitive DNA sequences (retrotransposons) [1, 2]. The composition of circulating DNA (cirDNA) from plasma and cell-surface-bound cirDNA (csb-cirDNA) was shown earlier to be altered in the blood of cancer patients due to accumulation of tumor-specific aberrantly methylated DNA fragments, which are currently considered valuable cancer markers [3, 4].
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$a Malignant cell transformation is accompanied by two processes of DNA methylation changes: hypermethylation in CpG islands of tumor suppressor genes and global hypomethylation in repetitive DNA sequences (retrotransposons) [1, 2]. The composition of circulating DNA (cirDNA) from plasma and cell-surface-bound cirDNA (csb-cirDNA) was shown earlier to be altered in the blood of cancer patients due to accumulation of tumor-specific aberrantly methylated DNA fragments, which are currently considered valuable cancer markers [3, 4].
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статьи в сборниках
Резюме
Malignant cell transformation is accompanied by two processes of DNA methylation changes: hypermethylation in CpG islands of tumor suppressor genes and global hypomethylation in repetitive DNA sequences (retrotransposons) [1, 2]. The composition of circulating DNA (cirDNA) from plasma and cell-surface-bound cirDNA (csb-cirDNA) was shown earlier to be altered in the blood of cancer patients due to accumulation of tumor-specific aberrantly methylated DNA fragments, which are currently considered valuable cancer markers [3, 4].