Delivery and reveal of localization of upconversion luminescent microparticles and quantum dots in the skin in vivo by fractional laser microablation, multimodal imaging, and optical clearing /E. K. Volkova, I. Y. Yanina, E. A. Genina [et.al.]

Электронный ресурс
Другой Автор
Volkova, Elena K.
Genina, Elina A.
Bashkatov, Alexey N.
Konyukhova, Julia G.
Popov, Alexey P.
Speranskaya, Elena S.
Bucharskaya, Alla B.
Navolokin, Nikita A.
Goryacheva, Irina Yu.
Yanina, Irina Yu.
Kochubey, Vyacheslav I.
Sukhorukov, Gleb B.
Meglinski, Igor V.
Tuchin, Valery V.
Источник
Journal of biomedical optics 2018 Vol. 23, № 2. P. 026001-1-026001-11
Аннотация
Delivery and spatial localization of upconversion luminescent microparticles [Y2O3:Yb, Er] (mean size ∼1.6  μm) and quantum dots (QDs) (CuInS2/ZnS nanoparticles coated with polyethylene glycol-based amphiphilic polymer, mean size ∼20  nm) inside rat skin was studied in vivo using a multimodal optical imaging approach. The particles were embedded into the skin dermis to the depth from 300 to 500  μm through microchannels performed by fractional laser microablation. Low-frequency ultrasound was applied to enhance penetration of the particles into the skin. Visualization of the particles was revealed using a combination of luminescent spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis. Optical clearing was used to enhance the image contrast of the luminescent signal from the particles. It was demonstrated that the penetration depth of particles depends on their size, resulting in a different detection time interval (days) of the luminescent signal from microparticles and QDs inside the rat skin in vivo. We show that luminescent signal from the upconversion microparticles and QDs was detected after the particle delivery into the rat skin in vivo during eighth and fourth days, respectively. We hypothesize that the upconversion microparticles have created a long-time depot localized in the laser-created channels, as the QDs spread over the surrounding tissues.
Всего оценка: 0
Нет записей для отображения.
 
 
 
03550nab a2200493 c 4500
001
 
 
vtls000628512
003
 
 
RU-ToGU
005
 
 
20180607082000.0
007
 
 
cr |
008
 
 
180606|2018    xxu     s         a eng d
024
7
$a 10.1117/1.JBO.23.2.026001 $2 doi
035
$a to000628512
039
9
$a 201806070820 $b cat202 $c 201806061628 $d VLOAD $y 201806061618 $z VLOAD
040
$a RU-ToGU $b rus $c RU-ToGU
245
1
0
$a Delivery and reveal of localization of upconversion luminescent microparticles and quantum dots in the skin in vivo by fractional laser microablation, multimodal imaging, and optical clearing $c E. K. Volkova, I. Y. Yanina, E. A. Genina [et.al.]
504
$a Библиогр.: 39 назв.
520
3
$a Delivery and spatial localization of upconversion luminescent microparticles [Y2O3:Yb, Er] (mean size ∼1.6  μm) and quantum dots (QDs) (CuInS2/ZnS nanoparticles coated with polyethylene glycol-based amphiphilic polymer, mean size ∼20  nm) inside rat skin was studied in vivo using a multimodal optical imaging approach. The particles were embedded into the skin dermis to the depth from 300 to 500  μm through microchannels performed by fractional laser microablation. Low-frequency ultrasound was applied to enhance penetration of the particles into the skin. Visualization of the particles was revealed using a combination of luminescent spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis. Optical clearing was used to enhance the image contrast of the luminescent signal from the particles. It was demonstrated that the penetration depth of particles depends on their size, resulting in a different detection time interval (days) of the luminescent signal from microparticles and QDs inside the rat skin in vivo. We show that luminescent signal from the upconversion microparticles and QDs was detected after the particle delivery into the rat skin in vivo during eighth and fourth days, respectively. We hypothesize that the upconversion microparticles have created a long-time depot localized in the laser-created channels, as the QDs spread over the surrounding tissues.
653
$a лазерная микроабляция
653
$a люминесцентные микрочастицы
653
$a кожа
653
$a оптическая когерентная томография
653
$a люминесцентная спектроскопия
653
$a мультимодальная визуализация
655
4
$a статьи в журналах
700
1
$a Volkova, Elena K.
700
1
$a Genina, Elina A.
700
1
$a Bashkatov, Alexey N.
700
1
$a Konyukhova, Julia G.
700
1
$a Popov, Alexey P.
700
1
$a Speranskaya, Elena S.
700
1
$a Bucharskaya, Alla B.
700
1
$a Navolokin, Nikita A.
700
1
$a Goryacheva, Irina Yu.
700
1
$a Yanina, Irina Yu.
700
1
$a Kochubey, Vyacheslav I.
700
1
$a Sukhorukov, Gleb B.
700
1
$a Meglinski, Igor V.
700
1
$a Tuchin, Valery V.
773
0
$t Journal of biomedical optics $d 2018 $g Vol. 23, № 2. P. 026001-1-026001-11 $x 1083-3668
852
4
$a RU-ToGU
856
7
$u http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000628512
908
$a статья
999
$a VIRTUA               
999
$a VTLSSORT0010*0030*0050*0070*0080*0240*0350*0390*0400*2450*5040*5200*6530*6531*6532*6533*6534*6535*6550*7000*7009*7001*7002*7003*7004*7005*7006*7007*7008*70010*70011*70012*70013*7730*8520*8560*9080*9992
Нет комментариев.
Предмет
статьи в журналах
Резюме
Delivery and spatial localization of upconversion luminescent microparticles [Y2O3:Yb, Er] (mean size ∼1.6  μm) and quantum dots (QDs) (CuInS2/ZnS nanoparticles coated with polyethylene glycol-based amphiphilic polymer, mean size ∼20  nm) inside rat skin was studied in vivo using a multimodal optical imaging approach. The particles were embedded into the skin dermis to the depth from 300 to 500  μm through microchannels performed by fractional laser microablation. Low-frequency ultrasound was applied to enhance penetration of the particles into the skin. Visualization of the particles was revealed using a combination of luminescent spectroscopy, optical coherence tomography, confocal microscopy, and histochemical analysis. Optical clearing was used to enhance the image contrast of the luminescent signal from the particles. It was demonstrated that the penetration depth of particles depends on their size, resulting in a different detection time interval (days) of the luminescent signal from microparticles and QDs inside the rat skin in vivo. We show that luminescent signal from the upconversion microparticles and QDs was detected after the particle delivery into the rat skin in vivo during eighth and fourth days, respectively. We hypothesize that the upconversion microparticles have created a long-time depot localized in the laser-created channels, as the QDs spread over the surrounding tissues.